References

N/A

Conclusion

This is the first study to look at predictors of intubation in COVID-19 patients treated with remdesivir. Remdesivir-associated bradycardia in COVID-19 patients may be associated with an increased rate of intubation and a potentially higher rate of in-hospital mortality. However, unforeseen complications of COVID-19, and unique patient characteristics cannot be excluded as potential contributors to the risk of intubation in this study. Further studies are needed to explore the risk of intubation in this patient population.

Results

A total of 77 patients were included and the mean age of the sample was 59.91±12.3 years. Of patients who met inclusion criteria, gender, hyperlipidemia, and bradycardia within the first 5 days of remedisivir were significant predictors of intubation. Males had higher odds (adjusted odds ratio = 1.887, 95% CI: 1.06-3.35) of intubation than their female counterparts. Patients who developed bradycardia within 5 days of remedisivir were more than twice likely to die as opposed to those who did not develop bradycardia (adjusted odds ratio =2.31, 95% CI: 1.352-3.948). Hyperlipidemic patients had higher odds of intubation as compared to non-hyperlipidemic patients (adjusted odds ratio=1.937, 95% CI: 1.083-3.464).

Methods

A single-institution retrospective study investigating COVID-19 treatment with remdesivir between March 1, 2020 and March 31, 2021 was performed. All remdesivir-treated COVID-19 patients who underwent endotracheal intubation in the inpatient setting were included in the study. All patients were analyzed for clinical characteristics that may be associated with an increased risk of intubation. A multivariate logistic regression model was fit to generate adjusted odds ratios for intubation as an outcome.

Introduction

Patients with severe coronavirus disease-19 (COVID-19) may require invasive respiratory management requiring endotracheal intubation. Remdesivir is an antiviral drug that has increased significantly in its use as a treatment for hospitalized patients with COVID-19. Few studies have investigated factors that can increase the risks of intubation, especially for those patients receiving remdesivir. The objective of this study was to investigate the factors that may predispose COVID-19 patients treated with remdesivir to require intubation.

Authors

Salman Mohammed BS, Kavita Batra PhD, Ariyon Schreiber MD, Justin Bauzon MD, Ahsan Chowdhury MD

Title

Predictors of Intubation In COVID-19 Patients Treated With Remdesivir: A Single Institution Retrospective Study